Callie and George - Grey's Anatomy
George and Callie began dating in Season 2, Callie fell hard for George; but their relationship was short lived, as George kept choosing his. Dr. Calliope ''Callie'' Torres has had a variety of relationships love life on the show started with her falling in love with George O'Malley, who. He and Callie divorced later and Izzie and George started up a relationship. However, after failing to recreate the great sex they had before, they decided that .
They've just changed something important in their lives forever. The first time we saw George, he failed at an appendectomy, he failed very publicly. In the elevator scene, if he hadn't been in that elevator, if they had been in any other place, he would have let someone else step in and deal with it.
The fact that it was only George and Alex forced him to act, it was either that or let this man die. He stepped up because he had to. He needs to be kind of kicked in the butt to do these things. However, when the actor starts to think he is so different from O'Malley, an awkward move can suggest otherwise.
I finished my line with her, and then I walked straight into the light stand. I have a really hard time with that kind of thing. I'm maybe a little too black and white about it.
They make good friends. We all have that friend we met in school or the gym or somewhere — we just hit it off right away. And right away there was no pretense or airs. That's Lexie and George. They're really good friends and I can see the friendship evolving into something even greater. Fans were "widely against" O'Malley's affair with Meredith in the second season,  however certain fans who supported their relationship were critical when Torres was introduced as a love interest for him.
He's slept with virtually everyone except the male cast and has been in love with virtually everyone except the male cast. And he's not that great of a doctor. And I admit this is a good lesson in Grey's viewing as well as life: Sit tight if you hate something, as nothing is permanent.
After watching that scene; so was I. This was a nasty side of Izzie I'd never seen before. I had trouble watching this story arc because Izzie is a well-loved character as far as the fans are concerned, however this storyline caused many fans to hate Izzie.
Callie Torres - Wikipedia
George effectively tells her to back off, but does she? Izzie keeps up her snide and nasty comments towards Callie, and eventually this blows up into a huge fight between Callie and George which ends with Callie kicking George out of their hotel room. He runs to Izzie, and tells her he needs to vent with alcohol, one thing leads to another and they end up sleeping together. She tells herself that their love-making was something falling into place.
Seems like she has forgotten all about George's wife Callie. When George remembers he confronts Izzie, and at first they are speechless. They meet up later in the locker room to talk.
George realises that Izzie expects George to tell Callie so they can be together.
George refuses to hurt Callie in this way and he chooses to remain in his marriage. Despite George telling Izzie to leave it alone, she refuses to listen and hounds George tirelessly. To the viewers she was a home-wrecker. George does not believe in divorce, so the thought of ending his marriage is very painful and if Izzie really was his best friend she would back off and let it be.
Izzie is convinced that her best friend George is now the love of her life and George is confused about his feelings too. I can't tell you how much I disliked Izzie in these scenes, and I doubt Katherine Heigl liked it either. However it takes a lot of talent to play the villian, some actors love playing the bad guy because it makes their character interesting.3x04 What I Am - Callie and George
He tells Izzie he cannot be there at Seattle Grace and see her everyday. While helping George fix his tie; Izzie tells him she is in love with him. At that moment the other interns walk in and start getting changed for the wedding. Patricia come in and hands out the intern exam results. George looks at his results and sees that he has failed the exam; he does not say anything to the others.
These doctors and Torres buy the hospital with the help of the Harper-Avery Foundation to prevent it from closing, and each become members of the new directing board. Everything seems to go well for Arizona and Callie, until a big storm hits the hospital now named after Mark Sloan and Lexie Grey. In the last episode of the ninth season, Arizona cheats on Callie with Dr.
Lauren Boswell Hilarie Burton. Callie soon discovers Arizona's infidelity by seeing her wedding ring pinned to Dr. In the aftermath of discovery, both Callie and Arizona share their feelings and it is revealed that Arizona does not forgive Callie for making the call to amputate her leg.
Callie is heartbroken and Arizona states that Callie lost nothing in the crash, to which Callie responds that she, apparently, lost Arizona. Callie takes Sofia to live with Meredith and Derek, Zola, and Baby Bailey for a while before kicking Arizona out of their apartment and celebrates by dancing in her underwear. Callie also left Arizona at therapy, telling her that she was the only one that needed to go. After being hit by a lawsuit, her father, Carlos, visits and tells Callie that he cheated on her mother but she took him back and Callie wouldn't be here if her mother didn't give Carlos a second chance.
Callie goes to Arizona's apartment and invites her to come back home.
Callie finds out during surgery that Arizona was sleeping with Leah, a second year resident, while separated. Although angry at Arizona, Callie still agrees to work things out.
After April's failed wedding to Matthew, Callie and Arizona bought a house together, a fresh start, away from the memories of their apartment. They later decided to try again for a second child. After talking about it, the couple agreed to postpone their dream to have another baby until they're on more solid footing as a couple. At the beginning of the eleventh season, Callie and Arizona gave therapy another chance in order to help mend their marriage.
They were made to go 30 days living separate lives in the same house with no sexual activity with others or each other. They come close to breaking that rule and had to start over and before the 30 days was up they eventually gave in and connected sexually again. At the end of the 30 days at the final therapy session Arizona realized she couldn't live without Callie; however Callie didn't feel the same and stated she felt suffocated and eventually walked out of therapy, ending their marriage.
Callie then goes on to date Penny, who was the resident in charge of Derek Shepard's case. She comes to a dinner party hosted by Meredith, who recognizes her.
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It is then discovered that Penny is going to be working at Grey Sloan Memorial. When everyone, including Callie, finds out who Penny actually is, they protest and try to get her off of the Grey Sloan Memorial residency line. She manages to stay on the line despite all the others' pleads and wishes. After Callie discloses her desire to move to New York with Penny and take her and Arizona's daughter, Sofia, with her, Arizona takes Callie to court for sole parental custody.
Callie loses custody of her daughter to Arizona and Penny moves to New York. After Arizona decides that both Sofia's moms deserve to be happy, Arizona presents Callie with plane tickets and offers a custody agreement that keeps Sofia in Seattle for the summer and then sharing her every other school year and Christmas. Callie is referenced occasionally by Arizona and Sofia after her departure from the show. At the conclusion of season 14, Arizona departs the show to move to New York and it is implied that the two will ultimately reconcile after Callie and Penny are mentioned to have broken up.